Tag: Alzheimer’s

Business World

Exalta launches the Mini ventilator with inbuilt oxygen concentrator

Oct 30, 2020 by Gouri Achary 0 Comments #Alzheimer’s, #Diabetes, #Exalta, #Mrs. Monika Singh, #toxicity

Since Covid-19 has arrived, the major issue faced by people is decreasing the oxygen level. This virus gives a direct impact on the lungs of a person, a person faces issues to inhale oxygen and exhale carbon dioxide properly. It’s a pure oxygen concentrator that provides 200mm hg of oxygen per minute. Secondly, it’s water-based. You just need to put the water inside and rest it’ll process on its own.

Exalta started working day and night since the day when Covid-19 started spreading rapidly to make equipment in India which helps people to maintain their oxygen level and came up with the Mini ventilator inbuilt oxygen concentrator.

It’s the most amazing fact is that it creates pure oxygen through the water like you see different oxygen concentrator in the market which is based on Normal PSA (Pressure Swing Adsorption), they consist of Pressure exhaust mechanism through which they pass oxygen through normal air with zeolite process.

Zeolite is the process that purifies the air and removes other gases into a compressor. The price ranges from 40, 000 to 50,000/-. Each and every oxygen concentrator are based on the same mechanism and 98% of them are Chinese.

It’s a very effective way to process oxygen through water. If you’ll consume it continuously for 15 minutes, you’ll be able to see the increase in oxygen level, flow rate, P.I. (Perfusion Index) level, and other functions in the body. It also helps in treating health problems like Alzheimer’s, Diabetes, toxicity, and many others because when your body starts getting proper oxygen these issues start getting resolved.

On the launch, Mrs. Monika Singh, Director Exalta said, “This product works as an Oxygen concentrator, Compressed Oxygen, and Mini Ventilator which is 100 % made in India with no foreign components used.. We’re calling it a Mini Ventilator because it can provide you with the oxygen at the pressure of 200mm Hg to the lungs. Which can act as a ventilator at your home. It’s portable, handy, and easy to carry.”

The main motive was to get effective Indian products at very affordable prices. One can keep this portable ventilator at their homes too so people don’t need to visit the hospital at the time of the emergency, they can be rescued at home itself. Cities like Delhi, Noida, and many more where the oxygen level in the air is very low. What will you do? It won’t be able to compress the air and gives quality oxygen to a person.

Health

How can we protect our elders from Alzheimer’s disease?

Sep 26, 2020 by Gouri Achary 0 Comments #Alzheimer’s, #Dr. Pradeep V. Mahajan, #Regenerative Medicine

Dr. Pradeep V. Mahajan, Regenerative Medicine Researcher, StemRx Bioscience Solutions Pvt. Ltd., Navi Mumbai

These days, many of us tend to lose touch with family and friends due to our hectic lifestyles. Imagine how it would be if the nerve cells in our brain lose touch with each other in a similar manner! We would possibly not be able to form a link between objects, people, and their names, or even perform simple day-to-day activities.

This is typically what happens in people suffering from Alzheimer’s disease. This neurodegenerative disease is caused by a progressive loss of nerve cells and impaired interconnections due to the accumulation of unwanted proteins in the brain (tau/amyloid). Over time, different areas of the brain begin to shrink. In fact, accumulation of these deposits might begin from the 4th or 5th decade of life of an individual and gradually lead to symptoms at a later age. Recent research has focused on an “unfolded protein response” in cases of Alzheimer’s disease, which in simple terms can be described as an aberrant response that is not protective. Activation of this response has been linked to age and accumulation of the aforementioned unwanted proteins. Despite knowledge regarding these mechanisms, we still do not know what exactly triggers this disease. It could be due to some genetic mutation, obesity, other neurological conditions, trauma, lifestyle habits, and many more. Therefore, it is difficult to prevent or even predict who or when a person will acquire the condition!

Furthermore, currently, there is no definitive drug or conventional therapy that can treat or even halt the progression of the condition. This means that families tend to see their loved ones deteriorate over time, both physically and psychologically—sometimes to the extent that they do not remember their own spouse or children OR even how to brush their teeth! Sounds very depressing, doesn’t it?

Worry not, there is a new branch of medical science—Regenerative Medicine and Cell-based Therapy, which is reaching newer heights with each passing day in the treatment of various diseases. This form of therapy aims to capitalize on the innate regenerative potential of the body through the use of cells and other molecules present within the body. Today, let us understand how molecular chaperones, which in simple terms are “helper molecules” and exosomes play a role in Alzheimer’s disease.

Molecular chaperones are like the quality analysts of proteins. They function to regulate the activity of the proteins in the body and are also capable of destroying proteins that “misbehave.” Therefore, the natural step ahead would be to utilize these for the treatment of Alzheimer’s disease. So, what these chaperones have been shown to do is that they prevent the proteins from clumping together in the brain, as seen in patients with Alzheimer’s disease. Therefore, these can protect against further memory and other deficits. The best part, these are naturally occurring molecules in the body, hence the immune system will not consider them foreign, and there are no associated side effects.

The other set of molecules are exosomes, which are little “packets” containing the genetic material, proteins, immune system cells, etc. that are released by cells and circulate through the body to the target areas. They form a means of communication between cells as well (messenger molecules). In the context of Alzheimer’s disease, exosomes have been shown to clear the neurofibrillary tangles and β-amyloid deposits, as well as reduce inflammation and oxidative stress in the brain. Studies have shown that mesenchymal cell-derived exosomes play a neuroprotective role that is also capable of regenerating injured tissues in the brain.

We now have definitive knowledge about these naturally occurring molecules. Chaperones and exosomes are the new “target-specific” agents; therefore, we can be sure that adjoining structures will not be harmed. In fact, we are in an era where molecule-, growth factor-based therapies are at the forefront of several types of research. There are no drugs involved so the treatment is not symptom-based, but considers the actual pathology.

Our goal is to ensure that the progression of the condition is halted or at least slowed down, so as to prevent cognitive decline. Our elders deserve to live life with dignity and treatment based on regenerative medicine is a definitive approach to ensure that. Through the use of cell-based therapy, we aim to enable patients age gracefully, independently and cherish the memories they have accumulated in their lifetime.